PUBLICATION
Role of SULT-mediated sulfation in the biotransformation of 2-butoxyethanol and sorbitan monolaurate: A study using zebrafish SULTs
- Authors
- Xi, Y., Seyoum, H., Liu, M.C.
- ID
- ZDB-PUB-160525-5
- Date
- 2016
- Source
- Aquatic toxicology (Amsterdam, Netherlands) 177: 19-21 (Journal)
- Registered Authors
- Keywords
- 2-Butoxyethanol, Cytosolic sulfotransferase, SULT, Sorbitan monolaurate, Sulfation, Zebrafish
- MeSH Terms
-
- Animals
- Biotransformation
- Cytosol/enzymology
- Ethylene Glycols/metabolism*
- Hexoses/metabolism*
- Hydrogen-Ion Concentration
- Sulfates/metabolism
- Sulfotransferases/metabolism*
- Surface-Active Agents/metabolism
- Water Pollutants, Chemical/metabolism
- Zebrafish/metabolism*
- PubMed
- 27218426 Full text @ Aquat. Toxicol.
Citation
Xi, Y., Seyoum, H., Liu, M.C. (2016) Role of SULT-mediated sulfation in the biotransformation of 2-butoxyethanol and sorbitan monolaurate: A study using zebrafish SULTs. Aquatic toxicology (Amsterdam, Netherlands). 177:19-21.
Abstract
2-Butoxyethanol and sorbitan monolaurate are major components of oil dispersants that are applied in large quantities to control oil spill in the aquatic environment. An important question is whether aquatic animals are equipped with mechanisms for the detoxification of these oil dispersant compounds. The current study aimed to examine whether zebrafish cytosolic sulfotransferases (SULTs) are capable of sulfating 2-butoxyethanol and sorbitan monolaurate. A systematic analysis of 18 zebrafish SULTs revealed that SULT3 ST1 showed the strongest sulfating activity toward 2-butoxyethanol, while SULT1 ST3 displayed the strongest sulfating activity toward sorbitan monolaurate. The pH-dependence of these two SULTs in mediating the sulfation of 2-butoxyethanol or sorbitan monolaurate was examined. Taken together, these results implied that SULT-mediated sulfation may function in the detoxification of these two oil dispersant compounds.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping