PUBLICATION

Retroreflective-type Janus microspheres as a novel contrast agent for enhanced optical coherence tomography

Authors
Zhang, J., Liu, J., Wang, L.M., Li, Z.Y., Yuan, Z.
ID
ZDB-PUB-160525-4
Date
2017
Source
Journal of biophotonics   10(6-7): 878-886 (Journal)
Registered Authors
Liu, Jing, Zhang, Jian
Keywords
Janus microsphere, contrast enhancement, optical coherence tomography, retroreflective-type
MeSH Terms
  • Animals
  • Contrast Media/chemistry*
  • Female
  • Imaging, Three-Dimensional*
  • Liver/diagnostic imaging
  • Male
  • Mice, Nude
  • Microspheres
  • Phantoms, Imaging
  • Tomography, Optical Coherence*
  • Zebrafish
PubMed
27218690 Full text @ J. Biophotonics
Abstract
Optical coherence tomography (OCT) is a well-developed technology that utilizes near-infrared light to reconstruct three-dimensional images of biological tissues with micrometer resolution. Improvements of the imaging contrast of the OCT technique are able to further widen its extensive biomedical applications. In this study, Janus microspheres were developed and used as a positive contrast agent for enhanced OCT imaging. Phantom and ex vivo liver tissue experiments as well as in vivo animal tests were conducted, which validated that Janus microspheres, as a novel type of OCT tracer, were very effective in improving the OCT imaging contrast. Working principle and SEM image of Janus microsphere (top). Enhanced OCT imaging (bottom) of Janus microspheres in zebrafish stomach (blue dash line) and sinusoids (green arrows) of nude liver.
Genes / Markers
Figures
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes