PUBLICATION
Neurotrophins and their Trk-receptors in the cerebellum of zebrafish
- Authors
- Gatta, C., Altamura, G., Avallone, L., Castaldo, L., Corteggio, A., D'Angelo, L., de Girolamo, P., Lucini, C.
- ID
- ZDB-PUB-160521-9
- Date
- 2016
- Source
- Journal of morphology 277: 725-36 (Journal)
- Registered Authors
- Keywords
- Brain, fish, neurotrophic factors, teleosts
- MeSH Terms
-
- Animals
- Blotting, Western
- Brain-Derived Neurotrophic Factor/metabolism
- Cerebellum/metabolism*
- Female
- Immunohistochemistry
- Male
- Nerve Growth Factors/metabolism*
- Receptors, Nerve Growth Factor/metabolism*
- Zebrafish/metabolism*
- Zebrafish Proteins/metabolism*
- PubMed
- 27197756 Full text @ J. Morphol.
Citation
Gatta, C., Altamura, G., Avallone, L., Castaldo, L., Corteggio, A., D'Angelo, L., de Girolamo, P., Lucini, C. (2016) Neurotrophins and their Trk-receptors in the cerebellum of zebrafish. Journal of morphology. 277:725-36.
Abstract
Neurotrophins (NTs) and their specific Trk-receptors are key molecules involved in the regulation of survival, proliferation, and differentiation of central nervous system during development and adulthood in vertebrates. In the present survey, we studied the expression and localization of neurotrophins and their Trk-receptors in the cerebellum of teleost fish Danio rerio (zebrafish). Teleostean cerebellum is composed of a valvula, body and vestibulolateral lobe. Valvula and body show the same three-layer structure as cerebellar cortex in mammals. The expression of NTs and Trk-receptors in the whole brain of zebrafish has been studied by Western blotting analysis. By immunohistochemistry, the localization of NTs has been observed mainly in Purkinje cells; TrkA and TrkB-receptors in cells and fibers of granular and molecular layers. TrkC was faintly detected. The occurrence of NTs and Trk-receptors suggests that they could have a synergistic action in the cerebellum of zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping