PUBLICATION
Uptake and accumulation of polystyrene microplastics in zebrafish (Danio rerio) and toxic effects in liver
- Authors
- Lu, Y., Zhang, Y., Deng, Y., Jiang, W., Zhao, Y., Geng, J., Ding, L., Ren, H.Q.
- ID
- ZDB-PUB-160308-2
- Date
- 2016
- Source
- Environmental science & technology 50(7): 4054-60 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Discriminant Analysis
- Fluorescent Dyes/metabolism
- Gills/drug effects
- Least-Squares Analysis
- Liver/drug effects
- Liver/metabolism*
- Male
- Metabolome/drug effects
- Metabolomics
- Oxidative Stress/drug effects
- Plastics/toxicity*
- Polystyrenes/metabolism*
- Polystyrenes/toxicity*
- Zebrafish/metabolism*
- PubMed
- 26950772 Full text @ Env. Sci. Tech.
Citation
Lu, Y., Zhang, Y., Deng, Y., Jiang, W., Zhao, Y., Geng, J., Ding, L., Ren, H.Q. (2016) Uptake and accumulation of polystyrene microplastics in zebrafish (Danio rerio) and toxic effects in liver. Environmental science & technology. 50(7):4054-60.
Abstract
Microplastics have become an emerging contaminant and caused widespread concern about its potential toxic effects. In this study, the uptake and tissue accumulation of polystyrene microplastics (PS-MPs) in zebrafish were detected, as well as the toxic effects in liver were investigated. The results showed that after 7 days of exposure, 5-μm diameter MPs accumulated in fish gill, liver, and gut, while 20-μm diameter MPs only accumulated in fish gill and gut. Histopathological analysis showed that both sizes of 5-μm and 70-nm PS-MPs caused inflammation and lipid accumulation in fish liver. PS-MPs also induced significantly increased activities of SOD and CAT, indicating oxidative stress was induced after MPs treatment. In addition, metabolomic analysis suggested that MPs exposure induced alterations of metabolic profiles in fish liver and disturbed the lipid and energy metabolism. These findings provide new insights into the toxic effects of MPs on fish.
Errata / Notes
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping