PUBLICATION

Building and re-building the heart by cardiomyocyte proliferation

Authors
Foglia, M.J., Poss, K.D.
ID
ZDB-PUB-160305-26
Date
2016
Source
Development (Cambridge, England)   143: 729-40 (Review)
Registered Authors
Foglia, Matthew, Poss, Kenneth D.
Keywords
Cardiomyocyte, Heart regeneration, Proliferation
MeSH Terms
  • Adult
  • Animals
  • Cell Cycle
  • Cell Proliferation
  • Heart/embryology*
  • Homeostasis
  • Humans
  • Mice
  • Myocardium/metabolism
  • Myocytes, Cardiac/cytology*
  • Organogenesis
  • Reactive Oxygen Species/metabolism
  • Regeneration/physiology*
  • Zebrafish/physiology
PubMed
26932668 Full text @ Development
Abstract
The adult human heart does not regenerate significant amounts of lost tissue after injury. Rather than making new, functional muscle, human hearts are prone to scarring and hypertrophy, which can often lead to fatal arrhythmias and heart failure. The most-cited basis of this ineffective cardiac regeneration in mammals is the low proliferative capacity of adult cardiomyocytes. However, mammalian cardiomyocytes can avidly proliferate during fetal and neonatal development, and both adult zebrafish and neonatal mice can regenerate cardiac muscle after injury, suggesting that latent regenerative potential exists. Dissecting the cellular and molecular mechanisms that promote cardiomyocyte proliferation throughout life, deciphering why proliferative capacity normally dissipates in adult mammals, and deriving means to boost this capacity are primary goals in cardiovascular research. Here, we review our current understanding of how cardiomyocyte proliferation is regulated during heart development and regeneration.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping