ZFIN ID: ZDB-PUB-160305-20
Nucleolar protein 4-like has a complex expression pattern in zebrafish embryos
Borah, S., Barrodia, P., Swain, R.K.
Date: 2016
Source: The International journal of developmental biology   60(1-2-3): 53-56 (Journal)
Registered Authors:
Keywords: diencephalon, telencephalon, trigeminal ganglia, spinal cord neuron, pronephros
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Embryo, Nonmammalian/embryology
  • Embryo, Nonmammalian/metabolism*
  • Gene Expression Profiling/methods*
  • Gene Expression Regulation, Developmental*
  • Humans
  • In Situ Hybridization
  • Nuclear Proteins/classification
  • Nuclear Proteins/genetics*
  • Phylogeny
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sequence Homology, Amino Acid
  • Zebrafish/embryology
  • Zebrafish/genetics*
  • Zebrafish Proteins/classification
  • Zebrafish Proteins/genetics*
PubMed: 26934290 Full text @ Int. J. Dev. Biol.
The nucleolar protein 4-like (NOL4L) gene is present on chromosome 20 (20q11.21) in humans. Parts of this gene have been shown to fuse with RUNX1 and PAX5 in acute myeloid leukemia and acute lymphoblastic leukemia, respectively. The normal function of NOL4L in humans and other organisms is not well understood. The expression patterns and functions of NOL4L homologs during vertebrate development have not been reported. We sought to address these questions by studying the expression pattern of zebrafish nol4l during embryogenesis. Our data show that Znol4l mRNA is expressed in multiple organs in zebrafish embryos. The sites of expression include parts of the brain, spinal cord, pronephros, hematopoietic cells and gut.