PUBLICATION
Impaired brain StAR and HSP70 gene expression in zebrafish exposed to Methyl-Parathion based insecticide
- Authors
- da Rosa, J.G., Koakoski, G., Piato, A.L., Bogo, M.R., Bonan, C.D., Barcellos, L.J.
- ID
- ZDB-PUB-151225-8
- Date
- 2016
- Source
- Journal of toxicology and environmental health. Part A 79(1): 1-7 (Journal)
- Registered Authors
- Bonan, Carla Denise
- Keywords
- none
- MeSH Terms
-
- Agrochemicals/toxicity
- Animals
- Brain Chemistry/drug effects*
- Gene Expression/drug effects
- HSP70 Heat-Shock Proteins/biosynthesis*
- Insecticides/toxicity*
- Male
- Methyl Parathion/toxicity*
- Phosphoproteins/biosynthesis*
- Receptors, Glucocorticoid/biosynthesis
- Receptors, Glucocorticoid/drug effects
- Water Pollutants, Chemical/toxicity
- Zebrafish
- PubMed
- 26699931 Full text @ J. Toxicol. Environ. Health. A.
Citation
da Rosa, J.G., Koakoski, G., Piato, A.L., Bogo, M.R., Bonan, C.D., Barcellos, L.J. (2016) Impaired brain StAR and HSP70 gene expression in zebrafish exposed to Methyl-Parathion based insecticide. Journal of toxicology and environmental health. Part A. 79(1):1-7.
Abstract
Fish production ponds and natural water body areas located in close proximity to agricultural fields receive water with variable amounts of agrochemicals, and consequently, compounds that produce adverse effects may reach nontarget organisms. The aim of this study was to investigate whether waterborne methyl-parathion-based insecticide (MPBI) affected gene expression patterns of brain glucocorticoid receptor (GR), steroidogenic acute regulatory protein (StAR), and heat shock protein 70 (hsp70) in adult zebrafish (Danio rerio) exposed to this chemical for 96 h. Treated fish exposed to MPBI-contaminated water showed an inhibition of brain StAR and hsp70 gene expression. Data demonstrated that MPBI produced a decrease brain StAR and hsp70 gene expression.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping