PUBLICATION
Enhanced Bioconcentration of Bisphenol A in the Presence of Nano-TiO2 Can Lead to Adverse Reproductive Outcomes in Zebrafish
- Authors
- Fang, Q., Shi, Q., Guo, Y., Hua, J., Wang, X., Zhou, B.
- ID
- ZDB-PUB-151224-11
- Date
- 2016
- Source
- Environmental science & technology 50(2): 1005-13 (Journal)
- Registered Authors
- Guo, YongYong, Zhou, BingSheng
- Keywords
- none
- MeSH Terms
-
- Animals
- Benzhydryl Compounds/pharmacokinetics
- Benzhydryl Compounds/toxicity*
- Biological Availability
- Endocrine Disruptors/pharmacokinetics
- Endocrine Disruptors/toxicity
- Estradiol/blood
- Female
- Follicle Stimulating Hormone/blood
- Luteinizing Hormone/blood
- Male
- Nanoparticles/toxicity*
- Ovary/drug effects
- Phenols/pharmacokinetics
- Phenols/toxicity*
- Reproduction/drug effects*
- Testis/drug effects
- Testosterone/blood
- Tissue Distribution
- Titanium/pharmacokinetics
- Titanium/toxicity*
- Vitellogenins/blood
- Water Pollutants, Chemical/pharmacokinetics
- Water Pollutants, Chemical/toxicity*
- Zebrafish*/physiology
- PubMed
- 26694738 Full text @ Env. Sci. Tech.
Citation
Fang, Q., Shi, Q., Guo, Y., Hua, J., Wang, X., Zhou, B. (2016) Enhanced Bioconcentration of Bisphenol A in the Presence of Nano-TiO2 Can Lead to Adverse Reproductive Outcomes in Zebrafish. Environmental science & technology. 50(2):1005-13.
Abstract
Titanium dioxide nanoparticles (n-TiO2) and bisphenol A (BPA) are widespread environmental contaminants in the aquatic environment. We hypothesized that n-TiO2 may adsorb BPA, and thus modify its bioavailability and toxicity to aquatic organisms. In this study, the bioavailability and toxicity of BPA (0, 2, 20, 200 µg/L) was investigated in the presence of n-TiO2 (100 µg/L). n-TiO2 sorbed BPA and the resulting nanoparticles were taken up by zebrafish, where they translocated to the liver, brain, and gonad tissues. Increased tissue burdens of both BPA and n-TiO2 were observed following co-exposure, and they also caused a reduction in plasma concentrations of estradiol (E2), testosterone (T), follicle-stimulating hormone (FSH), and luteinizing hormone (LH). Plasma vitellogenin (VTG) concentrations were significantly increased in males and females upon exposure to BPA. Histological examination of the ovary and testes did not show obvious morphological alterations; however, inhibition of egg production was noted in the presence of n-TiO2. The results indicated that n-TiO2 acts as a carrier of BPA and enhances its bioconcentration in zebrafish, leading to endocrine disruption and impairment of reproduction.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping