PUBLICATION
Hemodynamics driven cardiac valve morphogenesis
- Authors
- Steed, E., Boselli, F., Vermot, J.
- ID
- ZDB-PUB-151127-5
- Date
- 2016
- Source
- Biochimica et biophysica acta. Molecular cell research 1863(7 Pt B): 1760-6 (Review)
- Registered Authors
- Boselli, Francesco, Steed, Emily, Vermot, Julien
- Keywords
- Cell Mechanics, Mechanotransduction, Morphogenesis, Valvulopathy, Zebrafish
- MeSH Terms
-
- Animals
- Cell Differentiation
- Cell Lineage
- Cell Proliferation
- Gene Expression Regulation, Developmental
- Heart Valve Diseases*/embryology
- Heart Valve Diseases*/genetics
- Heart Valve Diseases*/metabolism
- Heart Valve Diseases*/physiopathology
- Heart Valves/embryology
- Heart Valves/growth & development*
- Heart Valves/metabolism
- Hemodynamics*
- Humans
- Kruppel-Like Transcription Factors/genetics
- Kruppel-Like Transcription Factors/metabolism
- Mechanotransduction, Cellular*
- Microscopy/methods
- Models, Animal
- Morphogenesis
- Stress, Mechanical
- Zebrafish*/embryology
- Zebrafish*/genetics
- Zebrafish*/growth & development
- Zebrafish*/metabolism
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 26608609 Full text @ BBA Molecular Cell Research
Citation
Steed, E., Boselli, F., Vermot, J. (2016) Hemodynamics driven cardiac valve morphogenesis. Biochimica et biophysica acta. Molecular cell research. 1863(7 Pt B):1760-6.
Abstract
Mechanical forces are instrumental to cardiovascular development and physiology. The heart beats approximately 2.6 billion times in a human lifetime and heart valves ensure these contractions result in an efficient, unidirectional flow of the blood. Composed of endocardial cells (EdCs) and extracellular matrix (ECM), cardiac valves are among the most mechanically challenged structures of the body both during and after their development. Understanding how hemodynamic forces modulate cardiovascular function and morphogenesis is key to unravelling the relationship between normal and pathological cardiovascular development and physiology. Most valve diseases have their origins in embryogenesis, either as signs of abnormal developmental processes or the aberrant re-expression of fetal gene programs normally quiescent in adulthood. Here we review recent discoveries in the mechanobiology of cardiac valve development and introduce the latest technologies being developed in the zebrafish, including live cell imaging and optical technologies, as well as modeling approaches that are currently transforming this field. This article is part of a Special Issue entitled:Cardiomyocyte Biology: Integration of Develomental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping