PUBLICATION
Individual Members of the Microbiota Disproportionately Modulate Host Innate Immune Responses
- Authors
- Rolig, A.S., Parthasarathy, R., Burns, A.R., Bohannan, B.J., Guillemin, K.
- ID
- ZDB-PUB-151117-9
- Date
- 2015
- Source
- Cell Host & Microbe 18: 613-20 (Journal)
- Registered Authors
- Guillemin, Karen
- Keywords
- none
- MeSH Terms
-
- Aeromonas/immunology
- Animals
- Germ-Free Life
- Immunization
- Microbiota*
- Models, Animal
- Models, Biological
- Neutrophils/immunology*
- Shewanella/immunology
- Symbiosis
- Vibrio/immunology
- Zebrafish/immunology*
- Zebrafish/microbiology
- PubMed
- 26567512 Full text @ Cell Host Microbe
Citation
Rolig, A.S., Parthasarathy, R., Burns, A.R., Bohannan, B.J., Guillemin, K. (2015) Individual Members of the Microbiota Disproportionately Modulate Host Innate Immune Responses. Cell Host & Microbe. 18:613-20.
Abstract
Predicting host health status based on microbial community structure is a major goal of microbiome research. An implicit assumption of microbiome profiling for diagnostic purposes is that the proportional representation of different taxa determine host phenotypes. To test this assumption, we colonized gnotobiotic zebrafish with zebrafish-derived bacterial isolates and measured bacterial abundance and host neutrophil responses. Surprisingly, combinations of bacteria elicited immune responses that do not reflect the numerically dominant species. These data are consistent with a quantitative model in which the host responses to commensal species are additive but where various species have different per capita immunostimulatory effects. For example, one species has a high per capita immunosuppression that is mediated through a potent secreted factor. We conclude that the proportional representation of bacteria in a community does not necessarily predict its functional capacities; however, characterizing specific properties of individual species offers predictive insights into multi-species community function.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping