PUBLICATION
Genome-wide gene expression profiling of acute metal exposures in male zebrafish
- Authors
- Baer, C.E., Ippolito, D.L., Hussainzada, N., Lewis, J.A., Jackson, D.A., Stallings, J.D.
- ID
- ZDB-PUB-151021-6
- Date
- 2014
- Source
- Genomics Data 2: 363-5 (Journal)
- Registered Authors
- Keywords
- Chromium, Cobalt, Nickel, Toxicogenomics, Whole organism, Zebrafish
- Datasets
- GEO:GSE50648
- MeSH Terms
- none
- PubMed
- 26484131 Full text @ Genom. Data
Citation
Baer, C.E., Ippolito, D.L., Hussainzada, N., Lewis, J.A., Jackson, D.A., Stallings, J.D. (2014) Genome-wide gene expression profiling of acute metal exposures in male zebrafish. Genomics Data. 2:363-5.
Abstract
To capture global responses to metal poisoning and mechanistic insights into metal toxicity, gene expression changes were evaluated in whole adult male zebrafish following acute 24 h high dose exposure to three metals with known human health risks. Male adult zebrafish were exposed to nickel chloride, cobalt chloride or sodium dichromate at concentrations corresponding to their respective 96 h LC20, LC40 and LC60 (i.e. 96 h concentrations at which 20%, 40% and 60% lethality is expected, respectively). Histopathology was performed on a subset of metal-exposed zebrafish to phenotypically anchor transcriptional changes associated with each metal exposure. Here we describe in detail the contents and quality controls for the gene expression and other data associated with the study published by Hussainzada and colleagues in BMC Pharmacology and Toxicology (Hussainzada et al., 2014) with the data uploaded to Gene Expression Omnibus (accession number GSE50648).
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping