PUBLICATION
Cross-species models of human melanoma
- Authors
- van der Weyden, L., Patton, E.E., Wood, G.A., Foote, A., Brenn, T., Arends, M.J., Adams, D.J.
- ID
- ZDB-PUB-150912-12
- Date
- 2016
- Source
- The Journal of pathology 238(2): 152-65 (Review)
- Registered Authors
- Patton, E. Elizabeth
- Keywords
- Melanoma, cross-species analysis, genome analysis
- MeSH Terms
-
- Animals
- Cell Line, Tumor
- Disease Models, Animal*
- Disease Progression
- Dogs
- Genetic Predisposition to Disease/genetics
- Genome
- Horses
- Humans
- Melanoma/genetics*
- Melanoma/therapy
- Mice
- Mice, Transgenic
- Mutation/genetics
- Neoplasm Transplantation
- Skin Neoplasms/genetics*
- Skin Neoplasms/therapy
- Transplantation, Heterologous
- Uveal Neoplasms/genetics
- Uveal Neoplasms/therapy
- Zebrafish
- PubMed
- 26354726 Full text @ J. Pathol.
Citation
van der Weyden, L., Patton, E.E., Wood, G.A., Foote, A., Brenn, T., Arends, M.J., Adams, D.J. (2016) Cross-species models of human melanoma. The Journal of pathology. 238(2):152-65.
Abstract
Although transformation of melanocytes to melanoma is rare, the rapid growth, systemic spread, as well as the chemoresistance of melanoma presents significant challenges for patient care. Here we review animal models of melanoma, including murine, canine, equine and zebrafish models, and detail the immense contribution these models have made to our knowledge of human melanoma development, and to melanocyte biology. We also highlight the opportunities for cross-species comparative genomic studies of melanoma to identify the key molecular events that drive this complex disease.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping