PUBLICATION
Phenolic Compounds from the Leaves and Twigs of Osteomeles schwerinae That Inhibit Rat Lens Aldose Reductase and Vessel Dilation in Zebrafish Larvae
- Authors
- Lee, I.S., Jung, S.H., Lee, Y.M., Choi, S.J., Sun, H., Kim, J.S.
- ID
- ZDB-PUB-150904-8
- Date
- 2015
- Source
- Journal of natural products 78(9): 2249-54 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Aldehyde Reductase/antagonists & inhibitors
- Animals
- Biphenyl Compounds/chemistry
- Biphenyl Compounds/isolation & purification*
- Biphenyl Compounds/pharmacology
- Drugs, Chinese Herbal/chemistry
- Drugs, Chinese Herbal/isolation & purification*
- Drugs, Chinese Herbal/pharmacology
- Glucose/analysis
- Glucose/pharmacology
- Glycosides/chemistry
- Glycosides/isolation & purification*
- Glycosides/pharmacology
- Larva/drug effects
- Lens, Crystalline/enzymology
- Molecular Structure
- Nuclear Magnetic Resonance, Biomolecular
- Plant Leaves/chemistry
- Plant Stems/chemistry
- Rats
- Retinal Vessels/drug effects
- Rosaceae/chemistry*
- Zebrafish/growth & development
- PubMed
- 26331986 Full text @ J. Nat. Prod.
Citation
Lee, I.S., Jung, S.H., Lee, Y.M., Choi, S.J., Sun, H., Kim, J.S. (2015) Phenolic Compounds from the Leaves and Twigs of Osteomeles schwerinae That Inhibit Rat Lens Aldose Reductase and Vessel Dilation in Zebrafish Larvae. Journal of natural products. 78(9):2249-54.
Abstract
Three new phenolic biphenyl derivatives (1-3) and one new lignan glycoside (4) were isolated from the leaves and twigs of Osteomeles schwerinae. The structures of the new compounds were established by spectroscopic data interpretation. The inhibitory effects of 1-4 on rat lens aldose reductase in vitro were examined, and compounds 1-3 markedly inhibited the enzyme with IC50 values of 3.8 to 13.8 μM. In addition, the effects of these isolates on the dilation of hyaloid-retinal vessels induced by high glucose (HG) in zebrafish larvae were investigated. Compound 1 was the most effective in reducing HG-induced dilation of hyaloid-retinal vessels.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping