PUBLICATION

Transgenerational inheritance of heart disorders caused by paternal bisphenol A exposure

Authors
Lombó, M., Fernández-Díez, C., González-Rojo, S., Navarro, C., Robles, V., Herráez, M.P.
ID
ZDB-PUB-150901-2
Date
2015
Source
Environmental pollution (Barking, Essex : 1987)   206: 667-678 (Journal)
Registered Authors
Keywords
Bisphenol A, Cardiac development, DNA methylation, Sperm mRNAs, Transgenerational inheritance
MeSH Terms
  • Animals
  • Benzhydryl Compounds/toxicity*
  • DNA Methylation/drug effects
  • Endocrine Disruptors/toxicity*
  • Female
  • Gene Expression Regulation, Developmental/drug effects
  • Heart Defects, Congenital/chemically induced*
  • Heart Defects, Congenital/embryology
  • Heart Defects, Congenital/genetics
  • Humans
  • Male
  • Organogenesis/drug effects
  • Organogenesis/genetics
  • Paternal Exposure/adverse effects*
  • Phenols/toxicity*
  • Receptor, Insulin/genetics
  • Receptor, Insulin/metabolism
  • Signal Transduction/drug effects
  • Spermatozoa/drug effects*
  • Zebrafish/genetics
  • Zebrafish/growth & development*
PubMed
26322593 Full text @ Environ. Pollut.
CTD
26322593
Abstract
Bisphenol A (BPA) is an endocrine disruptor used in manufacturing of plastic devices, resulting in an ubiquitous presence in the environment linked to human infertility, obesity or cardiovascular diseases. Both transcriptome and epigenome modifications lie behind these disorders that might be inherited transgenerationally when affecting germline. To assess potential effects of paternal exposure on offspring development, adult zebrafish males were exposed to BPA during spermatogenesis and mated with non-treated females. Results showed an increase in the rate of heart failures of progeny up to the F2, as well as downregulation of 5 genes involved in cardiac development in F1 embryos. Moreover, BPA causes a decrease in F0 and F1 sperm remnant mRNAs related to early development. Results reveal a paternal inheritance of changes in the insulin signaling pathway due to downregulation of insulin receptor β mRNAs, suggesting a link between BPA male exposure and disruption of cardiogenesis in forthcoming generations.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping