PUBLICATION
Differential embryotoxicity of the organic pollutants in rural and urban air particles
- Authors
- Mesquita, S.R., van Drooge, B.L., Oliveira, E., Grimalt, J.O., Barata, C., Vieira, N., Guimarães, L., Piņa, B.
- ID
- ZDB-PUB-150825-56
- Date
- 2015
- Source
- Environmental pollution (Barking, Essex : 1987) 206: 535-542 (Journal)
- Registered Authors
- Piņa, Benjamin
- Keywords
- Air pollution, Air quality, Danio rerio, Embryo toxicity, GC?MS, PM10, Toxicogenomics
- Datasets
- GEO:GSE53522
- MeSH Terms
-
- Air Pollutants/analysis
- Air Pollutants/toxicity*
- Rural Health*
- Humans
- Particulate Matter/analysis
- Particulate Matter/toxicity*
- Risk Assessment
- Animals
- Gene Expression Regulation, Developmental/drug effects
- Urban Health*
- Pancreas/drug effects
- Pancreas/embryology
- Zebrafish/embryology
- Particle Size
- Embryonic Development/drug effects*
- Embryonic Development/genetics
- Environmental Monitoring/methods*
- Embryo, Nonmammalian/drug effects
- Gene Ontology
- Lens, Crystalline/drug effects
- Lens, Crystalline/embryology
- PubMed
- 26298234 Full text @ Environ. Pollut.
Citation
Mesquita, S.R., van Drooge, B.L., Oliveira, E., Grimalt, J.O., Barata, C., Vieira, N., Guimarães, L., Piņa, B. (2015) Differential embryotoxicity of the organic pollutants in rural and urban air particles. Environmental pollution (Barking, Essex : 1987). 206:535-542.
Abstract
Airborne particulate matter (PM) is a recognized risk factor for human populations. Here we assessed the toxic potential of the organic constituents from PM collected in urban and rural sites during warm and cold periods of 2012/2013, and fractionated into 6 size fractions. The finest PM fraction (<0.5 μm) showed the highest biological activity (dioxin-like activity and fish embryotoxicity) in all samples, and the maximal activity was observed in rural samples from the cold period. Zebrafish embryo transcriptome analysis showed a strong induction of the AhR signaling pathway correlated to PAH concentrations. Oxidative stress-related genes and pancreatic and eye-lens gene markers appeared de-regulated in embryos exposed to urban extracts, whereas exposure to rural extracts affected genes implicated in basic cellular functions. The observed effects can be directly related to air pollution-related human disorders, suggesting different potential adverse outcomes for human populations exposed to air pollution from specific sources.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping