PUBLICATION

Building Zebrafish Neurobehavioral Phenomics: Effects of Common Environmental Factors on Anxiety and Locomotor Activity

Authors
Stewart, A.M., Kaluyeva, A.A., Poudel, M.K., Nguyen, M., Song, C., Kalueff, A.V.
ID
ZDB-PUB-150806-2
Date
2015
Source
Zebrafish   12(5): 339-48 (Journal)
Registered Authors
Kalueff, Allan V.
Keywords
none
MeSH Terms
  • Animals
  • Anxiety*
  • Environment*
  • Female
  • Male
  • Models, Animal*
  • Motor Activity*
  • Phenotype
  • Zebrafish/physiology*
PubMed
26244595 Full text @ Zebrafish
Abstract
Zebrafish are emerging as an important model organism for neurobehavioral phenomics research. Given the likely variation of zebrafish behavioral phenotypes between and within laboratories, in this study, we examine the influence and variability of several common environmental modifiers on adult zebrafish anxiety and locomotor activity. Utilizing the novel tank paradigm, this study assessed the role of various laboratory factors, including experimenter/handling, testing time and days, batch, and the order of testing, on the behavior of a large population of experimentally naive control fish. Although time of the day, experimenter identity, and order of testing had little effect on zebrafish anxiety and locomotor activity levels, subtle differences were found for testing days and batches. Our study establishes how zebrafish behaviors are modulated by common environmental/laboratory factors and outlines several implications for zebrafish neurobehavioral phenomics research.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping