PUBLICATION

Optogenetic neuromodulation: New tools for monitoring and breaking neural circuits

Authors
Knafo, S., Wyart, C.
ID
ZDB-PUB-150707-7
Date
2015
Source
Annals of physical and rehabilitation medicine   58(4): 259-64 (Other)
Registered Authors
Wyart, Claire
Keywords
Neuromodulation, Optogenetics, Sensorimotor integration, Zebrafish
MeSH Terms
  • Animals
  • Genes, Reporter
  • Humans
  • Monitoring, Physiologic/methods*
  • Neural Conduction/physiology*
  • Neurons/physiology*
  • Optogenetics*
  • Spinal Cord/cytology
  • Spinal Cord Injuries/physiopathology
  • Spinal Cord Injuries/rehabilitation
  • Zebrafish
PubMed
26143950 Full text @ Ann Phys Rehabil Med
Abstract
Optogenetics is the combination of optical tools to monitor (i.e. "reporters") or interfere (i.e. "actuators") with neural activity, and genetic techniques to restrain the expression of these reporters and actuators in the neuronal populations of interest. Such combination of optical and genetic tools, together with the emergence of new animal models such as the zebrafish larva, has proven extremely valuable is dissecting neural circuits. Optogenetics provide a new framework to address issues that are fundamentally dynamic processes, such as sensorimotor integration in the vertebrate spinal cord. By shifting from spatially targeted electrical stimulation to genetically targeted optical stimulation, optogenetic also opens new avenues for innovative neurorehabilitative strategies, in particular after spinal cord injury.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes