PUBLICATION

Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging

Authors
Fujisawa, K., Terai, S., Matsumoto, T., Takami, T., Yamamoto, N., Nishina, H., Furutani-Seiki, M., Sakaida, I.
ID
ZDB-PUB-150625-3
Date
2015
Source
PLoS One   10: e0129950 (Journal)
Registered Authors
Furutani-Seiki, Makoto
Keywords
none
MeSH Terms
  • Animals
  • Aging/genetics*
  • Oligonucleotide Array Sequence Analysis
  • Animals, Genetically Modified
  • Liver Neoplasms/metabolism
  • Transcription Factors/genetics
  • Transcription Factors/physiology*
  • Disease Progression
  • Gene Expression Profiling
  • Amino Acid Sequence
  • Phylogeny
  • Carcinogenesis/genetics*
  • Carcinoma, Hepatocellular/metabolism
  • Mice
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/physiology*
  • Cell Line
  • Sequence Homology, Amino Acid
  • Diethylnitrosamine/chemistry
  • Disease Models, Animal
  • Oryzias
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Molecular Sequence Data
  • Cell Transformation, Neoplastic*
  • Zebrafish
PubMed
26107180 Full text @ PLoS One
Abstract
Maid is a helix-loop-helix protein that is involved in cell proliferation. In order to further elucidate its physiological functions, we studied Maid activity in two small fish model systems. We found that Maid expression was greatest in zebrafish liver and that it increased following partial hepatectomy. Maid levels were also high in hepatic preneoplastic foci induced by treatment of zebrafish with diethylnitrosamine (DEN), but low in hepatocellular carcinomas (HCC), mixed tumors, and cholangiocarcinomas developing in these animals. In DEN-treated transgenic medaka overexpressing Maid, hepatic BrdU uptake and proliferation were reduced. After successive breedings, Maid transgenic medaka exhibited decreased movement and a higher incidence of abnormal spine curvature, possibly due to the senescence of spinal cord cells. Taken together, our results suggest that Maid levels can influence the progression of liver cancer. In conclusion, we found that Maid is important regulator of hepatocarconogenesis and aging.
Errata / Notes
This article is corrected by ZDB-PUB-220906-27.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping