PUBLICATION
Animal models for studying neural crest development: is the mouse different?
- Authors
- Barriga, E.H., Trainor, P.A., Bronner, M., Mayor, R.
- ID
- ZDB-PUB-150430-3
- Date
- 2015
- Source
- Development (Cambridge, England) 142: 1555-60 (Other)
- Registered Authors
- Bronner-Fraser, Marianne, Mayor, Roberto
- Keywords
- Chicken, Gene knockout, Mouse, Neural crest, Xenopus, Zebrafish
- MeSH Terms
-
- Animals
- Chick Embryo
- Gene Expression Regulation, Developmental/genetics
- Gene Expression Regulation, Developmental/physiology*
- Gene Knockout Techniques/methods*
- Mice
- Models, Animal*
- Neural Crest/embryology*
- Phenotype*
- Species Specificity
- Xenopus
- Zebrafish
- PubMed
- 25922521 Full text @ Development
Citation
Barriga, E.H., Trainor, P.A., Bronner, M., Mayor, R. (2015) Animal models for studying neural crest development: is the mouse different?. Development (Cambridge, England). 142:1555-60.
Abstract
The neural crest is a uniquely vertebrate cell type and has been well studied in a number of model systems. Zebrafish, Xenopus and chick embryos largely show consistent requirements for specific genes in early steps of neural crest development. By contrast, knockouts of homologous genes in the mouse often do not exhibit comparable early neural crest phenotypes. In this Spotlight article, we discuss these species-specific differences, suggest possible explanations for the divergent phenotypes in mouse and urge the community to consider these issues and the need for further research in complementary systems.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping