PUBLICATION
Chemokine-guided cell migration and motility in zebrafish development
- Authors
- Bussmann, J., Raz, E.
- ID
- ZDB-PUB-150313-3
- Date
- 2015
- Source
- The EMBO journal 34(10): 1309-1318 (Review)
- Registered Authors
- Bussmann, Jeroen, Raz, Erez
- Keywords
- cell migration, cytokines
- MeSH Terms
-
- Animals
- Cell Movement/physiology*
- Chemokines/metabolism*
- Cytokines/metabolism
- Female
- Male
- Models, Biological
- Neutrophils/metabolism
- Zebrafish
- PubMed
- 25762592 Full text @ EMBO J.
Citation
Bussmann, J., Raz, E. (2015) Chemokine-guided cell migration and motility in zebrafish development. The EMBO journal. 34(10):1309-1318.
Abstract
Chemokines are vertebrate-specific, structurally related proteins that function primarily in controlling cell movements by activating specific 7-transmembrane receptors. Chemokines play critical roles in a large number of biological processes and are also involved in a range of pathological conditions. For these reasons, chemokines are at the focus of studies in developmental biology and of clinically oriented research aimed at controlling cancer, inflammation, and immunological diseases. The small size of the zebrafish embryos, their rapid external development, and optical properties as well as the large number of eggs and the fast expansion in genetic tools available make this model an extremely useful one for studying the function of chemokines and chemokine receptors in an in vivo setting. Here, we review the findings relevant to the role that chemokines play in the context of directed single-cell migration, primarily in neutrophils and germ cells, and compare it to the collective cell migration of the zebrafish lateral line. We present the current knowledge concerning the formation of the chemokine gradient, its interpretation within the cell, and the molecular mechanisms underlying the cellular response to chemokine signals during directed migration.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping