PUBLICATION
Developing highER-throughput zebrafish screens for in-vivo CNS drug discovery
- Authors
- Stewart, A.M., Gerlai, R., Kalueff, A.V.
- ID
- ZDB-PUB-150303-4
- Date
- 2015
- Source
- Frontiers in behavioral neuroscience 9: 14 (Other)
- Registered Authors
- Gerlai, Robert T., Kalueff, Allan V.
- Keywords
- CNS drug discovery, big data, high-throughput screens, phenomics, zebrafish models
- MeSH Terms
- none
- PubMed
- 25729356 Full text @ Front. Behav. Neurosci.
Citation
Stewart, A.M., Gerlai, R., Kalueff, A.V. (2015) Developing highER-throughput zebrafish screens for in-vivo CNS drug discovery. Frontiers in behavioral neuroscience. 9:14.
Abstract
The high prevalence of brain disorders and the lack of their efficient treatments necessitate improved in-vivo pre-clinical models and tests. The zebrafish (Danio rerio), a vertebrate species with high genetic and physiological homology to humans, is an excellent organism for innovative central nervous system (CNS) drug discovery and small molecule screening. Here, we outline new strategies for developing higher-throughput zebrafish screens to test neuroactive drugs and predict their pharmacological mechanisms. With the growing application of automated 3D phenotyping, machine learning algorithms, movement pattern- and behavior recognition, and multi-animal video-tracking, zebrafish screens are expected to markedly improve CNS drug discovery.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping