PUBLICATION

Dedifferentiation, Transdifferentiation, and Proliferation: Mechanisms Underlying Cardiac Muscle Regeneration in Zebrafish

Authors
Kikuchi, K.
ID
ZDB-PUB-150301-11
Date
2015
Source
Current pathobiology reports   3: 81-88 (Review)
Registered Authors
Kikuchi, Kazu
Keywords
Cardiomyocyte, Dedifferentiation, Proliferation, Regeneration, Transdifferentiation, Zebrafish
MeSH Terms
none
PubMed
25722956 Full text @ Curr Pathobiol Rep
Abstract
The adult mammalian heart is increasingly recognized as a regenerative organ with a measurable capacity to replenish cardiomyocytes throughout its lifetime, illuminating the possibility of stimulating endogenous regenerative capacity to treat heart diseases. Unlike mammals, certain vertebrates possess robust capacity for regenerating a damaged heart, providing a model to understand how regeneration could be augmented in injured human hearts. Facilitated by its rich history in the study of heart development, the teleost zebrafish Danio rerio has been established as a robust model to investigate the underlying mechanism of cardiac regeneration. This review discusses the current understanding of the endogenous mechanisms behind cardiac regeneration in zebrafish, with a particular focus on cardiomyocyte dedifferentiation, transdifferentiation, and proliferation.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping