PUBLICATION
Dedifferentiation, Transdifferentiation, and Proliferation: Mechanisms Underlying Cardiac Muscle Regeneration in Zebrafish
- Authors
- Kikuchi, K.
- ID
- ZDB-PUB-150301-11
- Date
- 2015
- Source
- Current pathobiology reports 3: 81-88 (Review)
- Registered Authors
- Kikuchi, Kazu
- Keywords
- Cardiomyocyte, Dedifferentiation, Proliferation, Regeneration, Transdifferentiation, Zebrafish
- MeSH Terms
- none
- PubMed
- 25722956 Full text @ Curr Pathobiol Rep
Citation
Kikuchi, K. (2015) Dedifferentiation, Transdifferentiation, and Proliferation: Mechanisms Underlying Cardiac Muscle Regeneration in Zebrafish. Current pathobiology reports. 3:81-88.
Abstract
The adult mammalian heart is increasingly recognized as a regenerative organ with a measurable capacity to replenish cardiomyocytes throughout its lifetime, illuminating the possibility of stimulating endogenous regenerative capacity to treat heart diseases. Unlike mammals, certain vertebrates possess robust capacity for regenerating a damaged heart, providing a model to understand how regeneration could be augmented in injured human hearts. Facilitated by its rich history in the study of heart development, the teleost zebrafish Danio rerio has been established as a robust model to investigate the underlying mechanism of cardiac regeneration. This review discusses the current understanding of the endogenous mechanisms behind cardiac regeneration in zebrafish, with a particular focus on cardiomyocyte dedifferentiation, transdifferentiation, and proliferation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping