PUBLICATION
Total synthesis of Herbarin A and B, determination of their antioxidant properties and toxicity in zebrafish embryo model
- Authors
- Heimberger, J., Cade, H.C., Padgett, J., Sittaramane, V., Shaikh, A.
- ID
- ZDB-PUB-150219-7
- Date
- 2015
- Source
- Bioorganic & medicinal chemistry letters 25(6): 1192-5 (Other)
- Registered Authors
- Sittaramane, Vinoth
- Keywords
- Antioxidant properties, Natural products, Total synthesis, Toxicity, Zebrafish
- MeSH Terms
-
- Animals
- Antioxidants/chemical synthesis*
- Antioxidants/pharmacology
- Antioxidants/toxicity
- Cladosporium/chemistry
- Cladosporium/metabolism
- Embryo, Nonmammalian/drug effects
- Embryonic Development/drug effects
- Fatty Acids, Unsaturated/chemical synthesis*
- Fatty Acids, Unsaturated/chemistry
- Fatty Acids, Unsaturated/toxicity
- Models, Animal
- Pyrones/chemical synthesis*
- Pyrones/chemistry
- Pyrones/toxicity
- Zebrafish/growth & development
- PubMed
- 25690788 Full text @ Bioorg. Med. Chem. Lett.
Citation
Heimberger, J., Cade, H.C., Padgett, J., Sittaramane, V., Shaikh, A. (2015) Total synthesis of Herbarin A and B, determination of their antioxidant properties and toxicity in zebrafish embryo model. Bioorganic & medicinal chemistry letters. 25(6):1192-5.
Abstract
Herbarin A and B were isolated from the fungal strains of Cladosporium herbarum found in marine sponges Aplysina aerophoba and Callyspongia aerizusa. Total synthesis of Herbarin A and B was achieved by carrying out a multi-step synthesis approach, and the antioxidant properties were evaluated using FRAP assay. Toxicity of these compounds was determined using a zebrafish embryo model.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping