PUBLICATION
Influences of Domoic Acid Exposure on Cardiac Development and the Expression of Cardiovascular Relative Genes in Zebrafish (Daniorerio) Embryos
- Authors
- Hong, Z., Zhang, Y., Zuo, Z., Zhu, R., Gao, Y.
- ID
- ZDB-PUB-150219-5
- Date
- 2015
- Source
- Journal of biochemical and molecular toxicology 29(6): 254-60 (Journal)
- Registered Authors
- Keywords
- Cardiac Toxicity, Domoic Acid, Embryonic Development, Zebrafish
- MeSH Terms
-
- Animals
- Cardiotoxicity
- Dose-Response Relationship, Drug
- Embryo, Nonmammalian/drug effects*
- Gene Expression Regulation, Developmental/drug effects
- Heart/drug effects*
- Heart/embryology
- Kainic Acid/analogs & derivatives*
- Kainic Acid/toxicity
- Marine Toxins/toxicity*
- Organogenesis/drug effects*
- Organogenesis/genetics
- Real-Time Polymerase Chain Reaction
- Zebrafish
- PubMed
- 25691335 Full text @ J. Biochem. Mol. Toxicol.
- CTD
- 25691335
Citation
Hong, Z., Zhang, Y., Zuo, Z., Zhu, R., Gao, Y. (2015) Influences of Domoic Acid Exposure on Cardiac Development and the Expression of Cardiovascular Relative Genes in Zebrafish (Daniorerio) Embryos. Journal of biochemical and molecular toxicology. 29(6):254-60.
Abstract
Domoic acid (DA) is a highly toxic phycotoxin that is generated from marine diatoms Pseudonitzschia spp. It has been found that bivalves or cephalopods can accumulate DA to a high level through their feeding activities and cause illness or death in consumers. Zebrafish have been used as a model to investigate and characterize the developmental toxicity of DA. However, there is no report about the relationship between DA and cardiac development in zebrafish. Here, zebrafish embryos were exposed to DA with at the dose of 1, 10, 100, and 1000 ng/L. High mortality and some developmental toxicity including pericardial and yolk sac edema, dorsal curvature, and cardiac defects were observed in the DA-treated larvae. We found that DA exposure not only disrupted normal cardiac development but also altered the expression of some cardiac development correlated genes and calcium ion channels, such as Anf, Bnp, Atp2a2a, Atp2a2b, Ncx1h, Ryr2b, and Tbx5.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping