PUBLICATION
New insight into cancer aneuploidy in zebrafish
- Authors
- Zhang, G., Yang, J.Y., Cui, Z.
- ID
- ZDB-PUB-150127-5
- Date
- 2015
- Source
- International review of cell and molecular biology 314: 149-70 (Chapter)
- Registered Authors
- Zhang, GuangJun
- Keywords
- Aneuploidy, Cancer drivers, Cancer passengers, Comparative oncogenomics, Oncogene addiction, Oncogenes, Phylooncogenomics, Synthetic lethality, Tumor suppressor genes, Zebrafish
- MeSH Terms
-
- Aneuploidy*
- Animals
- Fish Diseases/genetics
- Fish Diseases/metabolism*
- Fish Diseases/pathology
- Genome*
- Humans
- Neoplasms, Experimental/genetics*
- Neoplasms, Experimental/metabolism
- Neoplasms, Experimental/pathology
- Zebrafish/genetics*
- Zebrafish/metabolism
- PubMed
- 25619717 Full text @ Int. Rev. Cell Mol. Biol.
Citation
Zhang, G., Yang, J.Y., Cui, Z. (2015) New insight into cancer aneuploidy in zebrafish. International review of cell and molecular biology. 314:149-70.
Abstract
Aneuploidy is one of the most common genetic alterations in cancer cell genomes. It greatly contributes to the heterogeneity of cancer cell genomes, and its roles in tumorigenesis are attracting more and more attentions. Zebrafish is emerging as a new genetic model for many human diseases including cancer. The zebrafish cancer model has shown an equivalent degree of aneuploidy as found in corresponding human cancers, thus it provides a great tool for us to study cancer aneuploidy and, in general, cancer biology. Here, we discuss some new advances of aneuploidy and the potential usages of this cancer model system.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping