PUBLICATION

Differential expression of protocadherin-19, protocadherin-17, and cadherin-6 in adult zebrafish brain

Authors

Liu, Q., Bhattarai, S., Wang, N., Sochacka-Marlowe, A.

ID

ZDB-PUB-150123-2

Date

2015

Source

The Journal of comparative neurology 523(9): 1419-42 (Journal)

Registered Authors

Liu, Qin

Keywords

RRID: 2DB-GENO-30619-2, RRID: AB_193290, RRID: AB_514497, RRID: BC_129243, RRID: XM_684743, Roche Cat. # 11093274910, cell adhesion molecules, cerebellum, motor nuclei, sensory systems

MeSH Terms

Female
Animals
Spinal Cord/metabolism
Male
Species Specificity
Zebrafish Proteins/metabolism*
RNA, Messenger/metabolism*
Zebrafish/metabolism*
Cadherins/metabolism*
In Situ Hybridization
Brain/metabolism*

(all 11)

PubMed

25612302 Full text @ J. Comp. Neurol.

Abstract

Cell adhesion molecule cadherins play important roles in both development and maintenance of adult structures. Most studies on cadherin expression have been carried out in developing organisms, but information on cadherin distribution in adult vertebrate brains is limited. In this study, we used in situ hybridization to examine mRNA expression of three cadherins, protocadherin-19, protocadherin-17 and cadherin-6 in adult zebrafish brain. Each cadherin exhibits a distinct expression pattern in the fish brain, with protocadherin-19 and protocadherin-17 showing much wider and stronger expression than that of cadherin-6. Both protocadherin-19 and protocadherin-17 expressing cells occur throughout the brain with strong expression in the ventromedial telencephalon, periventricular regions of the thalamus and anterior hypothalamus, stratum periventriculare of the optic tectum, dorsal tegmental nucleus, granular regions of the cerebellar body and valvula, and superficial layers of the facial and vagal lobes. Numerous sensory structures (e.g. auditory, gustatory, lateral line, olfactory and visual nuclei) and motor nuclei (e.g. oculomotor, trochlear, trigeminal motor, abducens and vagal motor nuclei) contain protocadherin-19 and/or protocadherin-17 expressing cell. Expression of these two protocadherins is similar in the ventromedial telencephalon, thalamus, hypothalamus, facial and vagal lobes, but substantially different in the dorsolateral telencephalon, intermediate layers of the optic tectum, and cerebellar valvula. In contrast to the two protocadherins, cadherin-6 expression is much weaker and limited in the adult fish brain. This article is protected bycopyright. All rights reserved.

Genes / Markers

Figures

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Expression

Gene	Fish	Conditions	Stage	Qualifier	Anatomy	Assay	Figure
cdh6	WT	standard conditions	Adult		caudal periventricular hypothalamus	ISH	Fig. 7
cdh6	WT	standard conditions	Adult		caudal tuberal nucleus	ISH	Fig. 7
cdh6	WT	standard conditions	Adult	Not Detected	caudal tuberculum	ISH	Fig. 7
cdh6	WT	standard conditions	Adult	Not Detected	central caudal thalamic nucleus	ISH	Fig. 7
cdh6	WT	standard conditions	Adult	Not Detected	central nucleus torus semicircularis	ISH	Fig. 9
cdh6	WT	standard conditions	Adult		corpus cerebelli	ISH	Fig. 12
cdh6	WT	standard conditions	Adult	Not Detected	dorsal caudal thalamic nucleus	ISH	Fig. 7
cdh6	WT	standard conditions	Adult		dorsal periventricular hypothalamus	ISH	Fig. 7
cdh6	WT	standard conditions	Adult		dorsal periventricular hypothalamus	ISH	Fig. 8
cdh6	WT	standard conditions	Adult	Not Detected	dorsal tegmental nucleus	ISH	Fig. 9

1 - 10 of 247

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Phenotype

Mutations / Transgenics

Human Disease / Model

Sequence Targeting Reagents

Fish

Fish
WT

Antibodies

Orthology

Engineered Foreign Genes

Mapping

Liu et al., 2015 ZDB-PUB-150123-2 PMID:25612302

Differential expression of protocadherin-19, protocadherin-17, and cadherin-6 in adult zebrafish brain

Liu et al., 2015

ZDB-PUB-150123-2
PMID:25612302