PUBLICATION
Characterization of two thymosins as immune-related genes in common carp (cyprinus carpio l.)
- Authors
- Xiao, Z., Shen, J., Feng, H., Liu, H., Wang, Y., Huang, R., Guo, Q.
- ID
- ZDB-PUB-150118-2
- Date
- 2015
- Source
- Developmental and comparative immunology 50(1): 29-37 (Journal)
- Registered Authors
- Keywords
- beta thymosin (Tβ), common carp, prothymosin alpha (ProTα), spring viraemia of carp virus (SVCV)
- MeSH Terms
-
- Animals
- Carps/genetics*
- Carps/immunology
- Fish Proteins/genetics*
- Fish Proteins/immunology
- Protein Precursors/genetics*
- Protein Precursors/immunology
- T-Lymphocytes/immunology
- Thymosin/analogs & derivatives*
- Thymosin/genetics
- Thymosin/immunology
- Ubiquitins/genetics*
- Ubiquitins/immunology
- Zebrafish/genetics
- PubMed
- 25596145 Full text @ Dev. Comp. Immunol.
Citation
Xiao, Z., Shen, J., Feng, H., Liu, H., Wang, Y., Huang, R., Guo, Q. (2015) Characterization of two thymosins as immune-related genes in common carp (cyprinus carpio l.). Developmental and comparative immunology. 50(1):29-37.
Abstract
Prothymosin alpha (ProTα) and thymosin beta (Tβ) belong to thymosin family, which consists of a series of highly conserved peptides involved in stimulating immune responses. ProTα b and Tβ are still poorly studied in teleost. Here, the full-length cDNAs of ProTα b and Tβ-like (Tβ-l) were cloned and identified in common carp (Cyprinus carpio L.). The expressions of carp ProTα b and Tβ-l exhibited rise-fall pattern and then trended to be stable during early development. After spring viraemia of carp virus (SVCV) infection, the carp ProTα b and Tβ-l transcripts were significantly up-regulated in some immune-related organs. When transiently over-expressed carp ProTα b and Tβ-l in zebrafish, these two proteins up-regulated the expressions of T lymphocytes-related genes (Rag 1, TCR-γ, CD4 and CD8α). These results suggest that carp ProTα b and Tβ may ultimately enhance the immune response during viral infection and modulate the development of T lymphocytes in teleost.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping