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ZIRC
ZFIN ID: ZDB-PUB-150101-3
Endothelial cell-initiated extravasation of cancer cells visualized in zebrafish
Kanada, M., Zhang, J., Yan, L., Sakurai, T., Terakawa, S.
Date: 2014
Source: PeerJ 2: e688 (Journal)
Registered Authors:
Keywords: Cancer cell, Endothelial cell, Extravasation, Fluorescence, In vivo imaging, Metastasis, Sunitinib, Tumor cell, VEGF, Zebrafish
MeSH Terms: none
PubMed: 25551022 Full text @ Peer J.
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ABSTRACT
The extravasation of cancer cells, a key step for distant metastasis, is thought to be initiated by disruption of the endothelial barrier by malignant cancer cells. An endothelial covering-type extravasation of cancer cells in addition to conventional cancer cell invasion-type extravasation was dynamically visualized in a zebrafish hematogenous metastasis model. The inhibition of VEGF-signaling impaired the invasion-type extravasation via inhibition of cancer cell polarization and motility. Paradoxically, the anti-angiogenic treatment showed the promotion, rather than the inhibition, of the endothelial covering-type extravasation of cancer cells, with structural changes in the endothelial walls. These findings may be a set of clues to the full understanding of the metastatic process as well as the metastatic acceleration by anti-angiogenic reagents observed in preclinical studies.
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