PUBLICATION
Zebrafish as a model to study live mucus physiology
- Authors
- Jevtov, I., Samuelsson, T., Yao, G., Amsterdam, A., Ribbeck, K.
- ID
- ZDB-PUB-141018-4
- Date
- 2014
- Source
- Scientific Reports 4: 6653 (Journal)
- Registered Authors
- Amsterdam, Adam, Jevtov, Irena
- Keywords
- Mucosal immunology, Pathogenesis
- MeSH Terms
-
- Animals
- Gastrointestinal Tract/physiology
- Models, Biological
- Mucins/genetics*
- Mucins/metabolism
- Mucus/physiology*
- Respiratory System/physiopathology
- Urogenital System/physiology
- Zebrafish/genetics*
- Zebrafish/physiology
- PubMed
- 25323747 Full text @ Sci. Rep.
Citation
Jevtov, I., Samuelsson, T., Yao, G., Amsterdam, A., Ribbeck, K. (2014) Zebrafish as a model to study live mucus physiology. Scientific Reports. 4:6653.
Abstract
Dysfunctional mucus barriers can result in important pulmonary and gastrointestinal conditions, but model systems to study the underlying causes are largely missing. We identified and characterized five mucin homologues in zebrafish, and demonstrated a strategy for fluorescence labeling of one selected mucin. These tools can be used for in vivo experiments and in pharmacological and genetic screens to study the dynamics and mechanisms of mucosal physiology.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping