PUBLICATION
Commentary: catching a conserved mechanism of ethanol teratogenicity
- Authors
- Lovely, C.B., Eberhart, J.K.
- ID
- ZDB-PUB-140827-6
- Date
- 2014
- Source
- Alcoholism, clinical and experimental research 38: 2160-3 (Other)
- Registered Authors
- Eberhart, Johann
- Keywords
- Fetal Alcohol Spectrum Disorder, Zebrafish
- MeSH Terms
-
- Animals
- Fetal Alcohol Spectrum Disorders/etiology*
- Neurotoxicity Syndromes/embryology*
- PubMed
- 25156611 Full text @ Alcoholism Clin. Exp. Res.
Citation
Lovely, C.B., Eberhart, J.K. (2014) Commentary: catching a conserved mechanism of ethanol teratogenicity. Alcoholism, clinical and experimental research. 38:2160-3.
Abstract
Background Due to its profound impact on human development, ethanol (EtOH) teratogenicity is a field of intense study. The complexity of variables that influence the outcomes of embryonic or prenatal EtOH exposure compels the use of animal models in which these variables can be isolated.
Methods Numerous model systems have been used in these studies. The zebrafish is a powerful model system, which has seen a recent increase in usage for EtOH studies.
Results Those using zebrafish for alcohol studies often face 2 questions: (i) How physiologically relevant are the doses of EtOH administered to zebrafish embryos? and (ii) Will the mechanisms of EtOH teratogenesis be conserved to other model systems and human?
Conclusions The current article by Flentke and colleagues () helps to shed important light on these questions and clearly demonstrates that the zebrafish will be a valuable model system with which to understand EtOH teratogenicity.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping