PUBLICATION
The POU-er of gene nomenclature
- Authors
- Frankenberg, S.R., Frank, D., Harland, R., Johnson, A.D., Nichols, J., Niwa, H., Schöler, H.R., Tanaka, E., Wylie, C., Brickman, J.M.
- ID
- ZDB-PUB-140724-5
- Date
- 2014
- Source
- Development (Cambridge, England) 141: 2921-3 (Journal)
- Registered Authors
- Harland, Richard
- Keywords
- none
- MeSH Terms
-
- Octamer Transcription Factor-3/genetics*
- Octamer Transcription Factor-3/physiology
- Stem Cells/cytology
- Animals
- Zebrafish
- Zebrafish Proteins/genetics*
- Zebrafish Proteins/physiology
- Cell Lineage
- Humans
- Vertebrates
- Cell Differentiation
- Developmental Biology/standards
- Phylogeny
- Terminology as Topic
- PubMed
- 25053425 Full text @ Development
Citation
Frankenberg, S.R., Frank, D., Harland, R., Johnson, A.D., Nichols, J., Niwa, H., Schöler, H.R., Tanaka, E., Wylie, C., Brickman, J.M. (2014) The POU-er of gene nomenclature. Development (Cambridge, England). 141:2921-3.
Abstract
The pluripotency factor POU5F1 (OCT4) is well known as a key regulator of stem cell fate. Homologues of POU5F1 exist throughout vertebrates, but the evolutionary and functional relationships between the various family members have been unclear. The level to which function has been conserved within this family provides insight into the evolution of early embryonic potency. Here, we seek to clarify the relationship between POU5F1 homologues in the vertebrate lineage, both phylogenetically and functionally. We resolve the confusion over the identity of the zebrafish gene, which was originally named pou2, then changed to pou5f1 and again, more recently, to pou5f3. We argue that the use of correct nomenclature is crucial when discussing the degree to which the networks regulating early embryonic differentiation are conserved.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping