PUBLICATION
NIR-triggered drug release from switchable rotaxane-functionalized silica-covered Au nanorods
- Authors
- Li, M., Yan, H., Teh, C., Korzh, V., Zhao, Y.
- ID
- ZDB-PUB-140716-15
- Date
- 2014
- Source
- Chemical communications (Cambridge, England) 50(68): 9745-8 (Journal)
- Registered Authors
- Teh, Cathleen
- Keywords
- none
- MeSH Terms
-
- Animals
- Azo Compounds/chemistry*
- Delayed-Action Preparations/chemistry*
- Drug Delivery Systems/instrumentation*
- Drug Liberation
- Gold/chemistry*
- Infrared Rays
- Nanotubes/chemistry*
- Rotaxanes/chemistry*
- Silicon Dioxide/chemistry*
- Zebrafish/embryology
- PubMed
- 25019373 Full text @ Chem. Commun. (Camb.)
Citation
Li, M., Yan, H., Teh, C., Korzh, V., Zhao, Y. (2014) NIR-triggered drug release from switchable rotaxane-functionalized silica-covered Au nanorods. Chemical communications (Cambridge, England). 50(68):9745-8.
Abstract
An NIR-triggered drug delivery system was developed by capping photo-switchable azobenzene-based rotaxane onto Au nanorod-mesoporous silica core-shell hybrids. Drug release from the nanocarrier in zebrafish embryo models could be controlled remotely under NIR irradiation, showing significant drug spreading to the adjacent tissues.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping