PUBLICATION
Zebrafish as a new model for phenotype-based screening of positive inotropic agents
- Authors
- Tang, C., Xie, D., Feng, B.
- ID
- ZDB-PUB-140706-16
- Date
- 2015
- Source
- Chemical Biology & Drug Design 85(3): 253-8 (Journal)
- Registered Authors
- Keywords
- heart failure, phenotype-based, positive inotropic agent, zebrafish
- MeSH Terms
-
- Animals
- Blood Pressure/drug effects
- Cardiotonic Agents/chemistry
- Cardiotonic Agents/pharmacology
- Cardiotonic Agents/therapeutic use*
- Digoxin/chemistry
- Digoxin/pharmacology
- Digoxin/therapeutic use*
- Disease Models, Animal
- Embryo, Nonmammalian/drug effects
- Embryo, Nonmammalian/physiology
- Heart/drug effects
- Heart/physiology
- Heart Failure/chemically induced
- Heart Failure/drug therapy*
- Heart Rate/drug effects
- Male
- Myocardium/pathology
- Phenotype
- Rats
- Rats, Sprague-Dawley
- Terfenadine/toxicity
- Zebrafish/growth & development
- PubMed
- 24990095 Full text @ Chem. Biol. Drug Des.
Citation
Tang, C., Xie, D., Feng, B. (2015) Zebrafish as a new model for phenotype-based screening of positive inotropic agents. Chemical Biology & Drug Design. 85(3):253-8.
Abstract
The zebrafish-based assay is a widely used animal model system for cardiovascular research. In this study, we investigated the cardiac defects caused by terfenadine and tested the pharmacological response of digoxin to zebrafish with cardiac defects. The study suggested that zebrafish could be a suitable model for phenotype-based screening and evaluation of positive inotropic agents. This phenotype-based, heart failure zebrafish model system was then utilized in in-house library screen. Some positive inotropic compound was discovered, which could attenuate the cardiac defects by increasing the flow velocity of caudal artery blood. This article is protected by copyright. All rights reserved.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping