PUBLICATION

Repairing quite swimmingly: advances in regenerative medicine using zebrafish

Authors
Goessling, W., North, T.E.
ID
ZDB-PUB-140629-9
Date
2014
Source
Disease models & mechanisms   7: 769-776 (Review)
Registered Authors
Goessling, Wolfram, North, Trista
Keywords
Disease model, Gastrointestinal, Hematovascular, Regeneration, Zebrafish
MeSH Terms
  • Animals
  • Genetic Testing
  • Humans
  • Regeneration/physiology*
  • Regenerative Medicine*
  • Translational Research, Biomedical
  • Zebrafish/physiology*
PubMed
24973747 Full text @ Dis. Model. Mech.
Abstract
Regenerative medicine has the promise to alleviate morbidity and mortality caused by organ dysfunction, longstanding injury and trauma. Although regenerative approaches for a few diseases have been highly successful, some organs either do not regenerate well or have no current treatment approach to harness their intrinsic regenerative potential. In this Review, we describe the modeling of human disease and tissue repair in zebrafish, through the discovery of disease-causing genes using classical forward-genetic screens and by modulating clinically relevant phenotypes through chemical genetic screening approaches. Furthermore, we present an overview of those organ systems that regenerate well in zebrafish in contrast to mammalian tissue, as well as those organs in which the regenerative potential is conserved from fish to mammals, enabling drug discovery in preclinical disease-relevant models. We provide two examples from our own work in which the clinical translation of zebrafish findings is either imminent or has already proven successful. The promising results in multiple organs suggest that further insight into regenerative mechanisms and novel clinically relevant therapeutic approaches will emerge from zebrafish research in the future.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes