PUBLICATION
Systemic Response to Ultraviolet Radiation Involves Induction of Leukocytic IL-1? and Inflammation in Zebrafish
- Authors
- Banerjee, S., Leptin, M.
- ID
- ZDB-PUB-140627-11
- Date
- 2014
- Source
- Journal of immunology (Baltimore, Md. : 1950) 193(3): 1408-15 (Journal)
- Registered Authors
- Leptin, Maria
- Keywords
- none
- MeSH Terms
-
- Inflammation Mediators/metabolism*
- Inflammation Mediators/radiation effects
- Animals
- Inflammation/etiology
- Inflammation/genetics
- Inflammation/mortality
- Signal Transduction/genetics
- Signal Transduction/immunology
- Signal Transduction/radiation effects
- Leukocytes/immunology
- Leukocytes/pathology
- Leukocytes/radiation effects*
- Embryo, Nonmammalian/immunology
- Embryo, Nonmammalian/pathology
- Embryo, Nonmammalian/radiation effects
- Larva/genetics
- Larva/immunology
- Larva/radiation effects
- Zebrafish/genetics
- Zebrafish/immunology*
- Animals, Genetically Modified
- Ultraviolet Rays/adverse effects
- Interleukin-1beta/biosynthesis*
- Interleukin-1beta/genetics
- Interleukin-1beta/radiation effects*
- NF-kappa B/genetics
- NF-kappa B/metabolism
- NF-kappa B/radiation effects
- Disease Models, Animal
- PubMed
- 24965777 Full text @ J. Immunol.
Citation
Banerjee, S., Leptin, M. (2014) Systemic Response to Ultraviolet Radiation Involves Induction of Leukocytic IL-1? and Inflammation in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 193(3):1408-15.
Abstract
Ultraviolet radiation is a pervasive stimulus with wide-ranging effects on all living forms. The effects of UV vary from physiological to pathological, depending on levels of exposure, but the immune response at the organismal level is not well understood. We use the zebrafish embryo and larva to study immune responses to UV stress in vivo. UV exposure causes inflammation characterized by systemic induction of proinflammatory cytokines. Leukocytes are an important component of this systemic response and upregulate IL-1β expression proportional to the dose of UV exposure. Increased levels of this proinflammatory cytokine counteract the lethal effect of high doses of UV.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping