PUBLICATION
Gene duplication followed by exon structure divergence substitutes for alternative splicing in zebrafish
- Authors
- Lambert, M.J., Olsen, K.G., Cooper, C.D.
- ID
- ZDB-PUB-140620-8
- Date
- 2014
- Source
- Gene 546(2): 271-6 (Journal)
- Registered Authors
- Cooper, Cynthia
- Keywords
- Alternative splicing, Gene duplication, Subfunctionalization, Zebrafish
- MeSH Terms
-
- Alternative Splicing*
- Animals
- Exons*
- Gene Duplication*
- Zebrafish/genetics*
- PubMed
- 24942242 Full text @ Gene
Citation
Lambert, M.J., Olsen, K.G., Cooper, C.D. (2014) Gene duplication followed by exon structure divergence substitutes for alternative splicing in zebrafish. Gene. 546(2):271-6.
Abstract
In this study we report novel findings regarding the evolutionary relationship between gene duplication and alternative splicing, two processes that increase proteomic diversity. By studying teleost fish, we find that gene duplication followed by exon structure divergence between paralogs, but not gene duplication alone, leads to a significant reduction in alternative splicing, as measured by both the proportion of genes that undergo alternative splicing as well as mean number of transcripts per gene. Additionally, we show that this effect is independent of gene family size and gene function. Furthermore, we provide evidence that the reduction in alternative splicing may be due to the partitioning of ancestral splice forms among the duplicate genes - a form of subfunctionalization. Taken together these results indicate that exon structure evolution subsequent to gene duplication may be a common substitute for alternative splicing.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping