PUBLICATION

Transcription factors involved in retinogenesis are co-opted by the circadian clock following photoreceptor differentiation

Authors
Laranjeiro, R., Whitmore, D.
ID
ZDB-PUB-140614-9
Date
2014
Source
Development (Cambridge, England)   141(13): 2644-56 (Journal)
Registered Authors
Laranjeiro, Ricardo, Whitmore, David
Keywords
none
MeSH Terms
  • Homeodomain Proteins/metabolism
  • Zebrafish Proteins/metabolism
  • Basic Helix-Loop-Helix Transcription Factors/metabolism
  • Immunohistochemistry
  • Gene Expression Regulation, Developmental/genetics
  • Gene Expression Regulation, Developmental/physiology*
  • Retina/embryology*
  • Transcription Factors/metabolism*
  • Blotting, Western
  • Reverse Transcriptase Polymerase Chain Reaction
  • Nerve Tissue Proteins/metabolism
  • Analysis of Variance
  • Animals
  • Circadian Clocks/physiology*
  • DNA Primers
  • Organogenesis/physiology*
  • In Situ Hybridization, Fluorescence
  • Bromodeoxyuridine
  • Cell Differentiation/physiology
  • Photoreceptor Cells/physiology*
  • Zebrafish/embryology*
(all 21)
PubMed
24924194 Full text @ Development
Abstract
The circadian clock is known to regulate a wide range of physiological and cellular processes, yet remarkably little is known about its role during embryo development. Zebrafish offer a unique opportunity to explore this issue, not only because a great deal is known about key developmental events in this species, but also because the clock starts on the very first day of development. In this study, we identified numerous rhythmic genes in zebrafish larvae, including the key transcriptional regulators neurod and cdx1b, which are involved in neuronal and intestinal differentiation, respectively. Rhythmic expression of neurod and several additional transcription factors was only observed in the developing retina. Surprisingly, these rhythms in expression commenced at a stage of development after these transcription factors are known to have played their essential role in photoreceptor differentiation. Furthermore, this circadian regulation was maintained in adult retina. Thus, once mature photoreceptors are formed, multiple retinal transcription factors fall under circadian clock control, at which point they appear to play a new and important role in regulating rhythmic elements in the phototransduction pathway.
Genes / Markers
Figures
Figure Gallery (9 images)
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Expression
Phenotype
No data available
Mutations / Transgenics
No data available
Human Disease / Model
No data available
Sequence Targeting Reagents
Target Reagent Reagent Type
neurod1MO1-neurod1MRPHLNO
1 - 1 of 1
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Fish
No data available
Antibodies
Orthology
No data available
Engineered Foreign Genes
No data available
Mapping
No data available
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Citation
Laranjeiro, R., Whitmore, D. (2014) Transcription factors involved in retinogenesis are co-opted by the circadian clock following photoreceptor differentiation. Development (Cambridge, England). 141(13):2644-56.