PUBLICATION
Müller glial cell reprogramming and retina regeneration
- Authors
- Goldman, D.
- ID
- ZDB-PUB-140605-3
- Date
- 2014
- Source
- Nature reviews. Neuroscience 15(7): 431-42 (Review)
- Registered Authors
- Goldman, Dan
- Keywords
- none
- MeSH Terms
-
- Animals
- Ependymoglial Cells/pathology
- Ependymoglial Cells/physiology*
- Humans
- Nerve Net/cytology
- Nerve Net/pathology
- Nerve Net/physiology
- Nerve Regeneration/physiology*
- Neuroglia/pathology
- Neuroglia/physiology
- Retina/cytology*
- Retina/pathology
- Retina/physiology*
- Signal Transduction/physiology
- PubMed
- 24894585 Full text @ Nat Rev Neurosci
Citation
Goldman, D. (2014) Müller glial cell reprogramming and retina regeneration. Nature reviews. Neuroscience. 15(7):431-42.
Abstract
Müller glia are the major glial component of the retina. They are one of the last retinal cell types to be born during development, and they function to maintain retinal homeostasis and integrity. In mammals, Müller glia respond to retinal injury in various ways that can be either protective or detrimental to retinal function. Although these cells can be coaxed to proliferate and generate neurons under special circumstances, these responses are meagre and insufficient for repairing a damaged retina. By contrast, in teleost fish (such as zebrafish), the response of Müller glia to retinal injury involves a reprogramming event that imparts retinal stem cell characteristics and enables them to produce a proliferating population of progenitors that can regenerate all major retinal cell types and restore vision. Recent studies have revealed several important mechanisms underlying Müller glial cell reprogramming and retina regeneration in fish that may lead to new strategies for stimulating retina regeneration in mammals.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping