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ZFIN ID: ZDB-PUB-140605-3
Müller glial cell reprogramming and retina regeneration
Goldman, D.
Date: 2014
Source: Nature reviews. Neuroscience   15(7): 431-42 (Review)
Registered Authors: Goldman, Dan
Keywords: none
MeSH Terms:
  • Animals
  • Ependymoglial Cells/pathology
  • Ependymoglial Cells/physiology*
  • Humans
  • Nerve Net/cytology
  • Nerve Net/pathology
  • Nerve Net/physiology
  • Nerve Regeneration/physiology*
  • Neuroglia/pathology
  • Neuroglia/physiology
  • Retina/cytology*
  • Retina/pathology
  • Retina/physiology*
  • Signal Transduction/physiology
PubMed: 24894585 Full text @ Nat Rev Neurosci
ABSTRACT
Müller glia are the major glial component of the retina. They are one of the last retinal cell types to be born during development, and they function to maintain retinal homeostasis and integrity. In mammals, Müller glia respond to retinal injury in various ways that can be either protective or detrimental to retinal function. Although these cells can be coaxed to proliferate and generate neurons under special circumstances, these responses are meagre and insufficient for repairing a damaged retina. By contrast, in teleost fish (such as zebrafish), the response of Müller glia to retinal injury involves a reprogramming event that imparts retinal stem cell characteristics and enables them to produce a proliferating population of progenitors that can regenerate all major retinal cell types and restore vision. Recent studies have revealed several important mechanisms underlying Müller glial cell reprogramming and retina regeneration in fish that may lead to new strategies for stimulating retina regeneration in mammals.
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