PUBLICATION
Through the looking glass: witnessing host-virus interplay in zebrafish
- Authors
- Levraud, J.P., Palha, N., Langevin, C., Boudinot, P.
- ID
- ZDB-PUB-140529-7
- Date
- 2014
- Source
- Trends in microbiology 22(9): 490-497 (Other)
- Registered Authors
- Levraud, Jean-Pierre
- Keywords
- in vivo imaging, innate immunity, tolerance, virus tropism, zebrafish
- MeSH Terms
-
- Animals
- Disease Models, Animal*
- Disease Resistance
- Host-Pathogen Interactions*
- Immunity, Innate
- Virus Diseases/immunology
- Virus Diseases/pathology
- Virus Replication
- Zebrafish/genetics
- Zebrafish/growth & development
- Zebrafish/immunology
- Zebrafish/virology*
- PubMed
- 24865811 Full text @ Trends Microbiol.
Citation
Levraud, J.P., Palha, N., Langevin, C., Boudinot, P. (2014) Through the looking glass: witnessing host-virus interplay in zebrafish. Trends in microbiology. 22(9):490-497.
Abstract
Host-pathogen interactions can be very complex at all scales; understanding organ- or organism-level events require in vivo approaches. Besides traditional host models such as mice, the zebrafish offers an attractive cocktail of optical accessibility and genetic tractability, blended with a vertebrate-type immunity, where innate responses can easily be separated from adaptive ones. Applied to viral infections, this model has revealed unexpected idiosyncrasies among organs, which we believe may apply to the human situation. We also argue that the dynamic analysis of virus spread and immune response in zebrafish make this model particularly well suited to the exploration of the concept of infection tolerance and resistance in relation to viral diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping