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ZFIN ID: ZDB-PUB-140516-11
A Pak1/Erk Signaling Module Acts through Gata6 to Regulate Cardiovascular Development in Zebrafish
Kelly, M.L., Astsaturov, A., Rhodes, J., Chernoff, J.
Date: 2014
Source: Developmental Cell 29: 350-9 (Journal)
Registered Authors: Rhodes, Jennifer
Keywords: none
MeSH Terms:
  • Animals
  • Cardiovascular Abnormalities/genetics
  • Cardiovascular System/embryology*
  • Cell Movement
  • Extracellular Signal-Regulated MAP Kinases/metabolism*
  • GATA Transcription Factors/metabolism*
  • Gene Expression Regulation, Developmental
  • Gene Knockdown Techniques
  • Heart/embryology
  • MAP Kinase Kinase 1/metabolism
  • Morpholinos/genetics
  • Neural Crest/embryology*
  • Phosphorylation
  • Signal Transduction/genetics
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish/metabolism
  • Zebrafish Proteins/metabolism*
  • p21-Activated Kinases/genetics
  • p21-Activated Kinases/metabolism*
PubMed: 24823378 Full text @ Dev. Cell
Proper neural crest development and migration is critical during embryonic development, but the molecular mechanisms regulating this process remain incompletely understood. Here, we show that the protein kinase Erk, which plays a central role in a number of key developmental processes in vertebrates, is regulated in the developing neural crest by p21-activated protein kinase 1 (Pak1). Furthermore, we show that activated Erk signals by phosphorylating the transcription factor Gata6 on a conserved serine residue to promote neural crest migration and proper formation of craniofacial structures, pigment cells, and the outflow tract of the heart. Our data suggest an essential role for Pak1 as an Erk activator, and Gata6 as an Erk target, during neural crest development.