PUBLICATION
Zebrafish as a model for zoonotic aquatic pathogens
- Authors
- Rowe, H.M., Withey, J.H., Neely, M.N.
- ID
- ZDB-PUB-140513-394
- Date
- 2014
- Source
- Developmental and comparative immunology 46(1): 96-107 (Journal)
- Registered Authors
- Neely, Melody N.
- Keywords
- Aquaculture, Aquatic pathogens, Bacteria, Environmental reservoir, Zebrafish, Zoonotic
- MeSH Terms
-
- Zebrafish/microbiology*
- Bacterial Physiological Phenomena
- Bacterial Infections/immunology*
- Animals
- Water Microbiology*
- Bacteria/classification
- Bacteria/immunology
- Humans
- Host-Pathogen Interactions
- PubMed
- 24607289 Full text @ Dev. Comp. Immunol.
Citation
Rowe, H.M., Withey, J.H., Neely, M.N. (2014) Zebrafish as a model for zoonotic aquatic pathogens. Developmental and comparative immunology. 46(1):96-107.
Abstract
Aquatic habitats harbor a multitude of bacterial species. Many of these bacteria can act as pathogens to aquatic species and/or non-aquatic organisms, including humans, that come into contact with contaminated water sources or colonized aquatic organisms. In many instances, the bacteria are not pathogenic to the aquatic species they colonize and are only considered pathogens when they come into contact with humans. There is a general lack of knowledge about how the environmental lifestyle of these pathogens allows them to persist, replicate and produce the necessary pathogenic mechanisms to successfully transmit to the human host and cause disease. Recently, the zebrafish infectious disease model has emerged as an ideal system for examining aquatic pathogens, both in the aquatic environment and during infection of the human host. This review will focus on how the zebrafish has been used successfully to analyze the pathogenesis of aquatic bacterial pathogens.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping