PUBLICATION

Whole-brain activity maps reveal stereotyped, distributed networks for visuomotor behavior

Authors
Portugues, R., Feierstein, C.E., Engert, F., Orger, M.B.
ID
ZDB-PUB-140513-305
Date
2014
Source
Neuron   81: 1328-43 (Journal)
Registered Authors
Engert, Florian
Keywords
none
MeSH Terms
  • Behavior, Animal/physiology*
  • Brain/physiology*
  • Brain Mapping
  • Neuroimaging/methods
  • Animals
  • Nerve Net/physiology*
  • Zebrafish/physiology*
  • Neurons/physiology*
(all 8)
PubMed
24656252 Full text @ Neuron
Abstract
Most behaviors, even simple innate reflexes, are mediated by circuits of neurons spanning areas throughout the brain. However, in most cases, the distribution and dynamics of firing patterns of these neurons during behavior are not known. We imaged activity, with cellular resolution, throughout the whole brains of zebrafish performing the optokinetic response. We found a sparse, broadly distributed network that has an elaborate but ordered pattern, with a bilaterally symmetrical organization. Activity patterns fell into distinct clusters reflecting sensory and motor processing. By correlating neuronal responses with an array of sensory and motor variables, we find that the network can be clearly divided into distinct functional modules. Comparing aligned data from multiple fish, we find that the spatiotemporal activity dynamics and functional organization are highly stereotyped across individuals. These experiments systematically reveal the functional architecture of neural circuits underlying a sensorimotor behavior in a vertebrate brain.
Genes / Markers
Figures
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Expression
No data available
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
b692
    		Point Mutation
    zf498TgTransgenic Insertion
      1 - 2 of 2
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      Human Disease / Model
      No data available
      Sequence Targeting Reagents
      No data available
      Fish
      Fish
      mitfab692/b692; zf498Tg
      1 - 1 of 1
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      Antibodies
      No data available
      Orthology
      No data available
      Engineered Foreign Genes
      Marker Marker Type Name
      GCaMPEFGGCaMP
      1 - 1 of 1
      Show
      Mapping
      No data available
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      Citation
      Portugues, R., Feierstein, C.E., Engert, F., Orger, M.B. (2014) Whole-brain activity maps reveal stereotyped, distributed networks for visuomotor behavior. Neuron. 81:1328-43.