PUBLICATION
Behavioral changes of zebrafish according to cisplatin-induced toxicity of the balance system
- Authors
- Kim, M., Choi, J., Kim, N., and Han, G.
- ID
- ZDB-PUB-140415-33
- Date
- 2014
- Source
- Human & Experimental Toxicology 33(11): 1167-75 (Journal)
- Registered Authors
- Keywords
- Zebrafish, behavior, cisplatin, toxicity, vestibule of ear
- MeSH Terms
-
- Animals
- Antineoplastic Agents/toxicity*
- Behavior, Animal/drug effects*
- Cisplatin/toxicity*
- Mechanoreceptors/drug effects
- Mechanoreceptors/pathology
- Swimming
- Zebrafish
- PubMed
- 24505048 Full text @ Hum. Exp. Toxicol.
Citation
Kim, M., Choi, J., Kim, N., and Han, G. (2014) Behavioral changes of zebrafish according to cisplatin-induced toxicity of the balance system. Human & Experimental Toxicology. 33(11):1167-75.
Abstract
Background and objectives: Zebrafish are commonly used as experimental animals in otolaryngology studies. However, the behavioral characteristics of
these fish are not well known, especially those related to the vestibular system. The goal of this study was to evaluate behavioral
changes in zebrafish due to toxicity in the balance system.
Materials and methods: Zebrafish were exposed to 1000 µM cisplatin for 6 h. We, then, periodically monitored swimming depth, total swimming distance, peak swimming velocity, and mean swimming velocity of the fish for approximately 21 days.
Results: Total swimming distance (p < 0.0001), peak swimming velocity (p = 0.0063), and mean swimming velocity (p < 0.0001) in the cisplatin-administered group were significantly decreased when compared with control fish.
Conclusion: Our findings demonstrate that cisplatin can alter the locomotion behavior of zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping