PUBLICATION

Inhibition and motor control in the developing zebrafish spinal cord

Authors
Fidelin, K., and Wyart, C.
ID
ZDB-PUB-140321-1
Date
2014
Source
Current opinion in neurobiology   26C: 103-109 (Journal)
Registered Authors
Wyart, Claire
Keywords
none
MeSH Terms
  • Animals
  • Interneurons/physiology
  • Motor Activity/genetics
  • Motor Activity/physiology*
  • Neural Inhibition/genetics
  • Neural Inhibition/physiology*
  • Spinal Cord/cytology*
  • Spinal Cord/growth & development*
  • Zebrafish
PubMed
24440416 Full text @ Curr. Opin. Neurobiol.
Abstract

Vertebrate locomotion relies on oscillatory activity along the spinal cord. Inhibition is involved in controlling the alternation of activity between each side and contributes in modulating propagation and termination of locomotor activity. Spinal inhibitory neurons are thought to regulate these mechanisms but the exact contribution of specific cell types remains difficult to tackle during active locomotion. In the past two decades, use of the transparent zebrafish larva has enabled morphological, functional, and genetic characterization of specific inhibitory spinal neurons. A wide range of new optical tools has been developed to monitor and to manipulate the activity of genetically targeted spinal populations. Combining these techniques with conventional electrophysiology will provide a better understanding of the contribution of inhibitory spinal interneurons in regulating essential features of locomotor patterns.

Genes / Markers
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes