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ZIRC
ZFIN ID: ZDB-PUB-131218-31
Velocity storage mechanism in zebrafish larvae
Chen, C.C., Bockisch, C.J., Bertolini, G., Olasagasti, I., Neuhauss, S.C., Weber, K.P., Straumann, D., and Huang, M.Y.
Date: 2014
Source: The Journal of physiology 592(Pt 1): 203-14 (Journal)
Registered Authors: Huang, Melody Ying-Yu, Neuhauss, Stephan
Keywords: Velocity storage mechanism, Zebrafish, velocity-to-position neural integrator
MeSH Terms:
  • Animals
  • Eye Movements*
  • Larva/physiology
  • Locomotion*
  • Photic Stimulation
  • Reflex, Vestibulo-Ocular*
  • Zebrafish
PubMed: 24218543 Full text @ J. Physiol.
ABSTRACT

The optokinetic reflex (OKR) and the angular vestibulo-ocular reflex (aVOR) complement each other to stabilize images on the retina despite self- or world motion, a joint mechanism that is critical for effective vision. It is currently hypothesized that signals from both systems integrate, in a mathematical sense, in a network of neurons operating as a velocity storage mechanism (VSM). When exposed to a rotating visual surround, subjects display the OKR, slow following eye movements frequently interrupted by fast resetting eye movements. Subsequent to light-off during optokinetic stimulation, eye movements do not stop abruptly, but decay slowly, a phenomenon referred to as the optokinetic after response (OKAR). The OKAR is most likely generated by the VSM. In this study, we observed the OKAR in developing larval zebrafish before the horizontal aVOR emerged. Our results suggest that the VSM develops prior to and without the need for a functional aVOR. It may be critical to ocular motor control in early development as it increases the efficiency of the OKR.

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