Bonger, K.M., Rakhit, R., Payumo, A.Y., Chen, J.K., and Wandless, T.J. (2014) General Method for Regulating Protein Stability with Light. ACS Chemical Biology. 9(1):111-5.
Post-translational regulation of protein abundance in cells is a powerful tool for studying protein function. Here, we describe a novel genetically encoded protein domain that is degraded upon exposure to nontoxic blue light. We demonstrate that fusion proteins containing this domain are rapidly degraded in cultured cells and in zebrafish upon illumination.
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