PUBLICATION
A systematic in-vivo toxicity evaluation of nanophosphor particles via zebrafish models
- Authors
- Jang, G.H., Hwang, M.P., Kim, S.Y., Jang, H.S., and Lee, K.H.
- ID
- ZDB-PUB-131108-23
- Date
- 2014
- Source
- Biomaterials 35(1): 440-449 (Journal)
- Registered Authors
- Keywords
- Zebrafish, Toxicity, Nanophosphor, Quantum dot
- MeSH Terms
-
- Animals
- Microscopy, Electron, Transmission
- Models, Animal*
- Nanoparticles/toxicity*
- Phosphorus Compounds/toxicity*
- Zebrafish/embryology*
- PubMed
- 24094937 Full text @ Biomaterials
Citation
Jang, G.H., Hwang, M.P., Kim, S.Y., Jang, H.S., and Lee, K.H. (2014) A systematic in-vivo toxicity evaluation of nanophosphor particles via zebrafish models. Biomaterials. 35(1):440-449.
Abstract
Lanthanide ion-doped nanophosphors are an emerging group of nanomaterials with excellent optical properties, and have been suggested as alternatives to quantum dots. In this letter, we determine the in-vitro and in-vivo toxicity of β-NaYF4:Ce,Tb nanophosphors using Capan-1 cells and embryonic zebrafish, respectively. In particular, we are the first to report on the in-vivo toxicity of β-phase nanophosphors and examine phenotypic developmental abnormalities (growth retardation, heart deformity, and bent tail), apoptotic cell death, and changes in heart function due to the nanophosphors. This study suggests the use of β-NaYF4:Ce,Tb nanophosphors as alternatives for QDs in a wide variety of biomedical imaging applications.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping