PUBLICATION

Dynamic expression of neurexophilin1 during zebrafish embryonic development

Authors

Thomas-Jinu, S., and Houart, C.

ID

ZDB-PUB-130806-6

Date

2013

Source

Gene expression patterns : GEP 13(8): 395-401 (Journal)

Registered Authors

Houart, Corinne

Keywords

neuroexophilins, synapses, neurexins, epiphysis, zebrafish, interneurons, neurons

MeSH Terms

Zebrafish Proteins/genetics
Zebrafish Proteins/metabolism*
Zebrafish/embryology
Zebrafish/metabolism*
Sequence Homology, Amino Acid
Embryonic Development
Molecular Sequence Data
Neuropeptides/genetics
Neuropeptides/metabolism*
Phylogeny
Neuroglia/metabolism
Spinal Cord/cytology
Spinal Cord/embryology
Spinal Cord/metabolism
Organ Specificity
Brain/cytology
Brain/embryology
Brain/metabolism
Interneurons/metabolism
Gene Expression*
Animals
Gene Expression Regulation, Developmental
Amino Acid Sequence
Glycoproteins/genetics
Glycoproteins/metabolism*

PubMed

23880144 Full text @ Gene Expr. Patterns

Abstract

Neurexophilin 1 (Nxph1) is a specific endoligand of α-neurexins that is essential for trans-synaptic activation. Here, we report its dynamic expression during development in zebrafish. Our study revealed an early onset of expression of nxph1. RT-PCR on a series of embryonic stages showed that it is maternally deposited, although only readily detectable by whole mount in situ hybridization by 22 hpf. During embryogenesis and larval stages, the zygotic transcript is expressed dynamically in various clusters of post-mitotic neurons and in glia in the central nervous system.

Genes / Markers

Figures