Gibbs, E.M., Horstick, E.J., and Dowling, J.J. (2013) Swimming into prominence: the zebrafish as a valuable tool for studying human myopathies and muscular dystrophies. The FEBS journal. 280(17):4187-97.
A new and exciting phase of muscle disease research has recently been entered. The application of next generation sequencing technology has spurred an unprecedented era of gene discovery for both myopathies and muscular dystrophies. Gene-based therapies for Duchenne muscular dystrophy have entered clinical trial, and several pathway-based therapies are doing so as well for a handful of muscle diseases. While many factors have aided the extraordinary developments in gene discovery and therapy development, the zebrafish model system has emerged as a vital tool in these advancements.
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