ZFIN ID: ZDB-PUB-130710-99
Swimming into prominence: the zebrafish as a valuable tool for studying human myopathies and muscular dystrophies
Gibbs, E.M., Horstick, E.J., and Dowling, J.J.
Date: 2013
Source: The FEBS journal   280(17): 4187-97 (Review)
Registered Authors: Dowling, Jim
Keywords: zebrafish, muscular dystrophy, birefringence, drug discovery, myopathy
MeSH Terms:
  • Animals
  • Biomedical Research*
  • Disease Models, Animal*
  • Humans
  • Muscular Diseases/genetics
  • Muscular Diseases/pathology*
  • Muscular Dystrophies/genetics
  • Muscular Dystrophies/pathology*
  • Zebrafish/genetics*
PubMed: 23809187 Full text @ FEBS J.
ABSTRACT

A new and exciting phase of muscle disease research has recently been entered. The application of next generation sequencing technology has spurred an unprecedented era of gene discovery for both myopathies and muscular dystrophies. Gene-based therapies for Duchenne muscular dystrophy have entered clinical trial, and several pathway-based therapies are doing so as well for a handful of muscle diseases. While many factors have aided the extraordinary developments in gene discovery and therapy development, the zebrafish model system has emerged as a vital tool in these advancements.

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