Role of Slit and Robo Proteins in the Development of Dopaminergic Neurons
- Authors
- Cornide-Petronio, M.E., and Barreiro-Iglesias, A.
- ID
- ZDB-PUB-130710-57
- Date
- 2013
- Source
- Developmental neuroscience 35(4): 285-92 (Review)
- Registered Authors
- Barreiro-Iglesias, Antón
- Keywords
- dopamine, Parkinson's disease, restless legs syndrome, spinal cord, schizophrenia, zebrafish
- MeSH Terms
-
- Animals
- Brain/cytology
- Brain/growth & development
- Dopaminergic Neurons/metabolism*
- Female
- Glycoproteins/metabolism*
- Mice
- Mutation/physiology
- Nerve Tissue Proteins/metabolism*
- Neural Pathways/growth & development
- Neural Pathways/physiology
- Pregnancy
- Primary Cell Culture
- Rats
- Receptors, Immunologic/metabolism*
- Signal Transduction/genetics
- Signal Transduction/physiology
- Zebrafish/physiology*
- PubMed
- 23796505 Full text @ Dev. Neurosci.
Dopamine plays a number of important roles in the nervous system and the dopaminergic system is affected in several brain disorders. It is therefore of great interest to study the axonal guidance systems that specifically participate in the correct establishment of dopaminergic projections during development and possibly during regenerative processes. In recent years, several reports have shown that Slits and their Robo receptors control the growth of longitudinal (both ascending and descending) mesodiencephalic dopaminergic axons to their appropriate target areas. In vitro studies have shown that Slit1, 2 and 3 are potent repellents of dopamine neurite extension. In vivo studies using both mice and zebrafish mutants for Slits and Robos have shown that Slits and Robos control the lateral and dorsoventral positioning of dopaminergic longitudinal projections during early development. In the present review, we aimed to compile the existing knowledge from both in vitro and in vivo studies on the role of Slit and Robo proteins in the development of dopaminergic neurons as a basis for future studies.